IMB turns 50
We are celebrating our 50th birthday October 23-24 with a scientific symposium featuring some of our esteemed alumni. Additional information can be found at http://www.molbio.uoregon.edu/IMB50.
The Institute of Molecular Biology at the University of Oregon is an interdisciplinary research community, founded in 1959, dedicated to investigating biological questions at the molecular level. Our collaborative and interactive Institute brings together--from the Departments of Biology, Chemistry, and Physics -- scientists using diverse approaches and state-of-the-art facilities. This rich research environment provides exceptional training opportunities for young scientists.
Evolutionary studies of the Wnt signaling pathway in the marine annelid Platynereis dumerilii. This new and emerging model organism is proving useful for understanding the evolution of developmental pathways that control animal body plans. Shown here are photomicrographs of 38-cell and 49-cell stage embryos. These images show fluorescent staining within fixed embryos stained for beta-catenin (red) and alpha-tubulin (green); views are from the animal pole. Tubulin marks the mitotic spindle, which helps to score cell division. beta-catenin is a key component of the Wnt signaling pathway that controls many developmental processes, including stem cell development, and is mutated in many important human cancers, including colon cancer.Bowerman Lab. For details, see Schneider and Bowerman, Developmental Cell 13, 73-86.
Recent IMB Research Publications
Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch Development 135(4):707-15. Herman Lab
Direct Spectroscopic Study of Reconstituted Transcription Complexes Reveals That Intrinsic Termination Is Driven Primarily by Thermodynamic Destabilization of the Nucleic Acid Framework. J. Biol. Chem. 283:3537-49 von Hippel Lab
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