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Oregon

IMB Retreat 2008

Evolutionary studies of the Wnt signaling pathway in the marine annelid Platynereis dumerilii. This new and emerging model organism is proving useful for understanding the evolution of developmental pathways that control animal body plans. Shown here are photomicrographs of 38-cell and 49-cell stage embryos. These images show fluorescent staining within fixed embryos stained for beta-catenin (red) and alpha-tubulin (green); views are from the animal pole. Tubulin marks the mitotic spindle, which helps to score cell division. beta-catenin is a key component of the Wnt signaling pathway that controls many developmental processes, including stem cell development, and is mutated in many important human cancers, including colon cancer.
Bowerman Lab
For details, see Schneider and Bowerman, Developmental Cell 13, 73-86.

 

Recent IMB Research Publications

Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
Development 135(4):707-15.
Herman Lab

Direct Spectroscopic Study of Reconstituted Transcription Complexes Reveals That Intrinsic Termination Is Driven Primarily by Thermodynamic Destabilization of the Nucleic Acid Framework.
J. Biol. Chem. 283:3537-49
von Hippel Lab

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