Prehoda Lab
Affiliations: Molecular Biology · Chemistry · Biology
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Recent News
Sept 23, 2009: Jana's paper on allosteric control of Discs Large is published
Sept 17, 2009: Chris' paper on inducing polarity in unpolarized cells to control the spindle is published
August 27, 2009: Rhonda Newman will be joining the stem cell division of Life Technologies. Congratulations Rhonda - we'll miss you!
June 19, 2009: Nick Smith will be speaking about his work on ultrasensitive regulation at this summer's Protein Society meeting.
June 9, 2009: Welcome to new graduate students Mike Drummond and Jon Mauser and summer student Lizzy Hubin.
May 8, 2009: Derek Ricketson has been awarded his PhD. Congratulations Derek!
Prehoda Lab Publications
2009
| Polarization of Drosophila Neuroblasts During Asymmetric Division Prehoda KE Cold Spring Harbor Perspectives in Biology |
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| Allosteric Control of Regulated Scaffolding in Membrane Associated Guanylate Kinases Marcette J, Hood IV, Johnston CA, Doe CQ, Prehoda KE Biochemistry |
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| Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells Johnston CA, Hirono K, Prehoda KE, Doe CQ Cell 138:1150-63 |
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| aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division Atwood SX, Prehoda KE Curr Biol 19:723-9 |
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| Intramolecular interactions between the SRC homology 3 guanylate kinase domains of discs large regulate its function in asymmetric cell division. Newman RA, Prehoda KE J Biol Chem 284:12924-32 |
2008
| Filament-dependent and -independent localization modes of Drosophila non-muscle myosin II Liu SL, Fewkes N, Ricketson D, Penkert RR, Prehoda KE J Biol Chem 283:380-7 |
2007
| Gαi generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. Nipper RW, Siller KH, Smith NR, Doe CQ, Prehoda KE Proc Natl Acad Sci 104:14306-11 |
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| Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE J Cell Sci 120:3200-6 |
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| Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF J Biol Chem 282:8446-53 |
2006
| Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder Qian Y, Prehoda KE J Biol Chem 281:35757-63 |
2005
| A polybasic motif allows N-WASP to act as a sensor of PIP(2) density Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA Mol Cell 17:181-91 |
2004
| Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex Penkert RR, DiVittorio HM, Prehoda KE Nat Struct Mol Biol 11:1122-7 |
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| Calcium channel function regulated by the SH3-GK module in beta subunits McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS Neuron 42:89-99 |
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| Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition Peterson FC, Penkert RR, Volkman BF, Prehoda KE Mol Cell 13:665-76 |
2002
| Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA Cell 111:565-76 |
2001
| Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE Mol Cell 8:1291-301 |